Figure 2.
Resting functional connectivity analysis. A. Medial frontal ROI seed region shows maximal connectivity with bilateral anterior insula/frontal operculum, paralleling the network activated during the CPT task. t map with n = 32 (16 patients, 16 controls), height threshold was made more stringent at p<0.001, FWE corrected to reveal connectivity maxima, extent threshold k=3 voxels. B. Results of ANOVA comparing patient and control connectivity between attention ROIs. Mean z-score for connectivity between right In/FO and MFC was 5.4 ± 2.0 (mean ± SD) for patients and 7.2 ± 1.9 for controls (p = 0.016); between left In/FO and MFC was 6.5 ± 2.5 for patients and 7.5 ± 2.9 for controls (p = 0.29); and between left In/FO and right In/FO was 7.3 ± 3.0 for patients and 8.9 ± 3.3 for controls (p = 0.16). Widths of arrows are proportional to F values. * = p<0.05.