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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Neuropharmacology. 2011 Mar 23;61(1-2):95–104. doi: 10.1016/j.neuropharm.2011.03.007

Figure 5. Antagonism of nicotinic receptors.

Figure 5

The day after steady nicotine self-administration (FR1) had been achieved, animals received (±)TCP (3 mg/kg, i.p.; black bars) or (+)TCP (1.5 mg/kg, i.p.; white bars) pretreatment and 45 min later either a saline (0.5 ml/kg, s.c.) or mecamylamine injection (1, 3 or 5 mg/kg, s.c.). Fifteen minutes later animals were allowed to self-administer nicotine (7.5 μg/kg/inj.). Mecamylamine had no affect in the (±)TCP-trained group (n=6/group), but caused a significant drop in responding in the (+)TCP-group (*p<0.05; **p<0.005 vs. baseline, n=6–7/group). Mean reinforced responses (+SEM) were plotted for each treatment group.