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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Neuropharmacology. 2011 Mar 23;61(1-2):95–104. doi: 10.1016/j.neuropharm.2011.03.007

Figure 6. Antagonism of serotonergic receptors.

Figure 6

The day after steady nicotine self-administration (FR1) had been achieved, animals received (±)TCP (3 mg/kg, i.p.; black bars) or (+)TCP (1.5 mg/kg, i.p.; white bars) pretreatment and 45 min later a ketanserin (1 mg/kg, s.c.) injection. Ketanserin caused a drop in responding in the (±)TCP-treated group (*p=0.008 vs. baseline, n=6), but not in the (+)TCP-trained group (n=5). Mean reinforced responses (+SEM) were plotted for each treatment group.