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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Neuropharmacology. 2011 Mar 23;61(1-2):95–104. doi: 10.1016/j.neuropharm.2011.03.007

Table 4.

Summary of Behavioral and Neurochemical Findings

Pretreatment
Experiment Saline 20-hr (±)TCP (−)TCP (+)TCP (±)TCP
MAO A & B Inhibition (MAO Assay) − + + + +
Acute TCP-Induced DA Release (Microdialysis) − − + + Minimal Effect +
Acute TCP-Induced 5-HT Release (Microdialysis) − − + − +
Nicotine-Induced DA Release (Microdialysis) − − − + +
Nicotine-Induced 5-HT Release (Microdialysis) − − − − −
FR1 Nicotine Self-Administration − + Minimal Effect + Minimal Effect + On Days 4–5 +
FR2–5 Nicotine Self- Administration − − + Minimal Effect + +
PR Nicotine Self- Administration − − − − +
nAChR Blockade (Mec) Nicotine Self-Administration N/A N/A N/A + −
Saline Substitution For i.v. Nicotine Self-Administration N/A N/A N/A + −
Cue Elimination Nicotine Self-Administration N/A N/A N/A − +
5-HT Receptor Blockade Ketanserin Nicotine Self-Administration N/A N/A N/A − +
Saline i.p. Substitution Nicotine Self-Administration N/A N/A N/A + +
Norharmane i.p. Substitution Nicotine Self-Administration N/A N/A N/A N/A +

(−) = Not significantly influenced or behavior not observed; (+) = Significant effect observed; N/A = Not Applicable (Experiment Not Performed); FR: Fixed Ratio, PR: Progressive Ratio