Skip to main content
. Author manuscript; available in PMC: 2012 Jun 13.
Published in final edited form as: Brain Res. 2011 Apr 22;1395:94–107. doi: 10.1016/j.brainres.2011.04.036

Figure 1. Chronic expression of hSNCA in DA neurons in SN leads to SNCA accumulation and a time-dependent loss of DA neurons.

Figure 1

hSNCA expression (pseudo-colored purple) in rat SN at 4 weeks (a) and 9 weeks (b) after injection of AAV-CBA-hSNCA is shown. TH-IR is shown in red. Note reduced TH-IR at 9 weeks, but not at 4 weeks after injection. Size bar, 100 μm. (c) Higher magnification of DA neurons showing accumulation of hSNCA-IR in DA perikarya and fibers (arrowheads). Size bar, 10 μm