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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Neuropharmacology. 2011 Feb 19;61(1-2):12–24. doi: 10.1016/j.neuropharm.2011.02.010

TABLE I.

Selectivity of protein kinase inhibitorsa

Inhibitor Protein Kinase Concentration References
SB 203580 α- and β-p38 MAPK 10 µM Cuenda et al., 1995
GF 109203X PKC 5 µM Heikkilä et al. 1993
PD 98059 MKK 10 µM Kim et al., 1997
LY 294002 PI3-K 50 µM Vlahos et al., 1994
Akti-1/2 Akt1 and Akt2 10 µM Barnett et al., 2005
Rapamycin mTORC1 0.1 µM Slack and Blusztjn, 2008
CID 755673 PKD 25 µM Sharlow et al., 2008
a

The concentrations of protein kinase inhibitors were selected with reference to tabulated data of their target selectivities as determined by Davies et al., 2000 and Bain et al., 2007. More specific information regarding concentrations that achieve effective inhibition of each targeted protein kinase in cultured cells was obtained from the references shown in the Table. The full chemical name of each protein kinase inhibitor is provided in the list of abbreviations.