TABLE I.
Selectivity of protein kinase inhibitorsa
| Inhibitor | Protein Kinase | Concentration | References |
|---|---|---|---|
| SB 203580 | α- and β-p38 MAPK | 10 µM | Cuenda et al., 1995 |
| GF 109203X | PKC | 5 µM | Heikkilä et al. 1993 |
| PD 98059 | MKK | 10 µM | Kim et al., 1997 |
| LY 294002 | PI3-K | 50 µM | Vlahos et al., 1994 |
| Akti-1/2 | Akt1 and Akt2 | 10 µM | Barnett et al., 2005 |
| Rapamycin | mTORC1 | 0.1 µM | Slack and Blusztjn, 2008 |
| CID 755673 | PKD | 25 µM | Sharlow et al., 2008 |
a
The concentrations of protein kinase inhibitors were selected with reference to tabulated data of their target selectivities as determined by Davies et al., 2000 and Bain et al., 2007. More specific information regarding concentrations that achieve effective inhibition of each targeted protein kinase in cultured cells was obtained from the references shown in the Table. The full chemical name of each protein kinase inhibitor is provided in the list of abbreviations.