Table 1.

Groups and Parameters in Experiments (Values are Mean ± SD)

Group	Sample	Body Weight (g)		TBI (ATM)	Righting Time (min)	Rectal Temp. (°C)		Temporalis Temp. (°C)
		Pre-TBI	Pre-MWM			Pre-TBI	Post-TBI	Pre-TBI	Post-TBI
Dose-response study: 24-hour histology
TBI + Saline	16	315 ± 16	-	2.15 ± 0.01	14.7 ± 3.4	37.1 ± 0.3	37.1 ± 0.3	35.7 ± 0.3	35.6 ± 0.3
TBI + PGI-02776 1mg/kg	10	317 ± 13	-	2.14 ± 0.01	12.1 ± 3.6	37.1 ± 0.4	37.0 ± 0.3	35.8 ± 0.4	35.8 ± 0.4
TBI + PGI-02776 10mg/kg	9	313 ± 7	-	2.14 ± 0.02	13.6 ± 4.3	37.2 ± 0.3	37.1 ± 0.2	36.0 ± 0.4	36.0 ± 0.3
TBI + PGI-02776 50mg/kg	10	315 ± 13	-	2.15 ± 0.01	12.9 ± 3.6	37.3 ± 0.2	37.2 ± 0.2	35.9 ± 0.3	35.9 ± 0.3
Optimal dose: Behavior and 16-day histology
Sham TBI + Saline	5	309 ± 7	322 ± 13	-	3.1 ± 0.3	37.1 ± 0.1	-	36.0 ± 0.2	-
TBI + Saline	10	316 ± 17	313 ± 14	2.15 ± 0.01	12.8 ± 2.6	37.0 ± 0.3	36.8 ± 0.3	35.9 ± 0.2	35.8 ± 0.2
TBI + PGI-02776 10mg/kg	10	314 ± 15	316 ± 18	2.15 ± 0.02	12.7 ± 3.8	36.9 ± 0.3	36.8 ± 0.3	35.9 ± 0.2	35.7 ± 0.3