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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Neuropharmacology. 2011 Mar 21;61(1-2):112–120. doi: 10.1016/j.neuropharm.2011.03.014

Figure 4. Inhibition of mNET-Y151F and mDAT-F155Y by cocaine analogs.

Figure 4

The removal of a hydroxyl group at mNET residue 151 (Y151F) significantly increased the potency of RTI-113 (p<0.001, n=6) in inhibiting uptake, while the addition of a hydroxyl group at the corresponding residue in mDAT (F155Y) had significant opposite effect (p<0.001, n=6) (A). In contrast, these mutations did not significantly alter the inhibition potencies of RTI-31, (p>0.05, n=3–6) (B).