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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: J Card Fail. 2011 Mar 26;17(6):472–478. doi: 10.1016/j.cardfail.2011.02.003

Table 4.

Age- and Gender-Adjusted Multivariate Cox Proportional Hazards Analyses of Time to Adverse Clinical Events in Chronic HF subjects (n=130).

3 year Death/Transplant
(27 events)
Variable HR (95% CI) p-value
Univariable Model
 NGAL (ng/mL)* 1.76 (1.19 – 2.58) 0.004
Multivariable Model 1
 NGAL (ng/mL)* 1.68 (1.08 – 2.57) 0.022
 LVEF (%)* 1.15 (0.71 – 1.88) 0.578
 Mitral E/Ea* 1.21 (0.82 – 1.64) 0.309
Multivariable Model 2
 NGAL (ng/mL)* 1.06 (0.66 – 1.84) 0.831
 Cystatin C (ng/mL)* 1.69 (1.06 – 2.59) 0.027
Multivariable Model 3
 NGAL (ng/mL)* 1.40 (0.92 – 2.21) 0.117
 NT-proBNP (pg/mL)* 1.59 (1.03 – 2.48) 0.038

Abbreviations: NGAL, neutrophil gelatinase-associated lipocalin; LVEF, left ventricular ejection fraction; NT-proBNP, amino-terminal pro-B-type natriuretic peptide.

*

All multivariable models adjusted for age and gender. Abbreviations: NGAL, cystatin C and NT-proBNP are natural logarithmic transformed. Hazard ratios per 1 SD increment (1 SD Ln NGAL = 0.58 ng/mL, 1 SD Age = 13.4 years; 1 SD LVEF = 5.9%; 1 SD E/septal Ea = 12.0; 1 SD Ln Cystatin C = 0.34 ng/mL; 1 SD Ln NT-proBNP = 1.27 pg/mL).