Skip to main content
. 2011 Feb 8;2:189. doi: 10.1038/ncomms1190

Figure 6. Regenerative capacity of Müller glial cells mediated by TrkB signalling.

Figure 6

(a, b) Treatment with BDNF (100 ng ml−1 for 1–2 days) induced expression of nestin (a) and Mash1 (b) in cultured Müller cells from WT but not TrkBGFAP KO mice. (c, d) Expression of Hes1 and Mash1 (c) and CaMKII (d) in BDNF-treated Müller cells from WT (white bar) and TrkBGFAP KO (black bar) mice. Note the upregulation of CaMKIIδ and Mash1 in WT but not TrkBGFAP KO Müller cells. Data are shown as the mean+s.e.m. (n=4). *P<0.01. (e, f) Treatment with platelet-derived growth factor (PDGF; 50 ng ml−1 for 24 h) induced expression of nestin (e) and Mash1 (f) in cultured Müller cells from WT and TrkBGFAP KO mice. Scale bars, 150 μm (a, e) and 50 μm (b, f).