Table 2.
Separate GEE models measuring decline in cognitive function associated with vascular risk factors
| Predictors | Outcome: Composite Cognitive z-score | |||
|---|---|---|---|---|
| Age-Adjusted | Multivariable-Adjusted* | |||
| B | p-value | β | p-value | |
| Total Cholesterol | 0.000 | 0.95 | −0.001 | 0.31 |
| Time*total cholesterol | −0.001 | 0.04 | −0.001 | 0.03 |
| HDL (log transformed) | 0.345 | 0.02 | 0.219 | 0.15 |
| Time*HDL | −0.024 | 0.61 | −0.057 | 0.20 |
| Triglycerides (log transformed) | −0.165 | 0.15 | −0.146 | 0.22 |
| Time*triglycerides | −0.013 | 0.66 | −0.006 | 0.85 |
| LDL | 0.001 | 0.70 | −0.001 | 0.31 |
| Time*LDL | −0.001 | 0.04 | −0.001 | 0.045 |
| Diabetes | −0.105 | 0.37 | −0.083 | 0.46 |
| Time*Diabetes | −0.051 | 0.03 | −0.050 | 0.045 |
| Hypertension | −0.207 | 0.16 | −0.210 | 0.14 |
| Time*Hypertension | 0.012 | 0.77 | 0.000 | 0.99 |
| History of Stroke | −0.026 | 0.88 | −0.052 | 0.77 |
| Time*Stroke | −0.045 | 0.29 | −0.043 | 0.31 |
| History of Heart Disease | 0.049 | 0.69 | 0.023 | 0.91 |
| Time*Heart Disease | −0.072 | 0.07 | −0.058 | 0.16 |
| Ever Smoked (baseline) | −0.106 | 0.28 | −0.035 | 0.68 |
| Time*Ever Smoked | 0.027 | 0.36 | 0.029 | 0.33 |
All models also included the following covariates, entered simultaneously: time, age at incidence, sex, race/ethnicity, education (years), and study cohort. Models for lipid variables additionally controlled for and time between the lipid draw and dementia incidence. Time was expressed in years.
Significant (p<0.05) coefficients are bolded.