Table 2.
Genomic features or DNA related attributes associated with Alu methylation entropy
| Attribute name | Direction of changea | Statistical test | Significance (not adjusted) | Significance (Bonferroni) | Significance threshold (FDR) |
|---|---|---|---|---|---|
| GC content | Increase | WilcoxonRankSum | 1.24E-08 | 3.50E-06 | 3.53E-05 |
| tetraNT_AATT | Decrease | WilcoxonRankSum | 3.63E-08 | 1.03E-05 | 7.07E-05 |
| tetraNT_TAAT | Decrease | WilcoxonRankSum | 1.25E-07 | 3.55E-05 | 1.06E-04 |
| cCount | Increase | WilcoxonRankSum | 2.12E-07 | 5.99E-05 | 1.41E-04 |
| tetraNT_CCCT | Increase | WilcoxonRankSum | 3.04E-07 | 8.60E-05 | 1.77E-04 |
| in Intron | Decrease | Chi-Square test | 5.80E-06 | 1.64E-03 | 2.12E-04 |
| tetraNT_ATTA | Decrease | WilcoxonRankSum | 6.10E-06 | 1.73E-03 | 2.47E-04 |
| tetraNT_ATTT | Decrease | WilcoxonRankSum | 1.52E-05 | 4.29E-03 | 2.83E-04 |
| tetraNT_ATAT | Decrease | WilcoxonRankSum | 2.96E-05 | 8.37E-03 | 3.18E-04 |
| distance to most adjacent CGI | Decrease | WilcoxonRankSum | 5.34E-05 | 1.51E-02 | 3.53E-04 |
| tetraNT_TAGT | Decrease | WilcoxonRankSum | 5.82E-05 | 1.65E-02 | 3.89E-04 |
| tetraNT_AAAT | Decrease | WilcoxonRankSum | 6.10E-05 | 1.73E-02 | 4.24E-04 |
| tetraNT_CCCC | Increase | WilcoxonRankSum | 6.13E-05 | 1.73E-02 | 4.59E-04 |
| tetraNT_TTTA | Decrease | WilcoxonRankSum | 1.17E-04 | 3.30E-02 | 4.95E-04 |
| tetraNT_TATA | Decrease | WilcoxonRankSum | 1.40E-04 | 3.97E-02 | 5.30E-04 |
| cgRatio | Decrease | WilcoxonRankSum | 1.57E-04 | 4.43E-02 | 5.65E-04 |
| tetraNT_AATA | Decrease | WilcoxonRankSum | 1.67E-04 | 4.71E-02 | 6.01E-04 |
aThe direction of change (increase or decrease) indicated the association of genomic region with high methylation entropy with the genomic features or DNA related attributes examined.