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. 2011 Jan 25;39(10):4438–4449. doi: 10.1093/nar/gkr019

Figure 4.

Figure 4.

Structure of the lysine channel. (A) Comparison of the lysine channels of Smyd3 and SET7/9 (PDB code 1O9S). Superposition of the active sites of Smyd3 and SET7/9 reveals a narrow channel in Smyd3 which is similar to the lysine channel of SET7/9. The key residues forming the lysine channel are shown with ball-and-stick models. The color coding is the same as in Figure 1A. (B) Superposition of the active sites of Smyd3 and pea Rubisco LSMT (PDB code 1P0Y). The residues are shown with ball-and-stick models, and for clarity, the side chains of Asn181 of Smyd3 and Arg222 of Rubisco LSMT are hidden. The color coding for Smyd3 is the same as in Figure 1A, and Rubisco LSMT is colored in light gray. (C) HKMT activity of the wild-type Smyd3 and the mutants carrying point mutations at the lysine channel.