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. 2011 Jan 25;39(10):4035–4047. doi: 10.1093/nar/gkq1305

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Published by Oxford University Press 2011.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Hierarchical clustering demonstrates specific effects of PDGF-AA and PDGF–BB on miR expression in U118 cells. (A) Differential expression of miRs is induced by PDGF-AA and PDGF-BB at different timepoints. Among other miRs, let-7d is suppressed by PDGF-AA (see arrow). (B) Effects of PDGF-BB on miR expression (0 versus 12 h). Among other miRs, miR-146b is induced by PDGF-BB (see arrow). qPCR quantifies let-7d expression levels in U118 MG (C), C272/hTert/E7 (D), SH-SY5Y (E) and WI38 cells (F) after PDGF-AA treatment. Statistical significance is marked by asterisks.