Table 2.
Specific PDGF BB inducible or repressible microRNAs
| miR | Chromosome | Fold-changes | P-value | Expression in cancer | Function |
|---|---|---|---|---|---|
| miR-106b | 7q22.1 | 4.6 | 0.0433 | Up in prostate cancer | Suppresses E2F1 and p21 |
| miR-30b | 8q24 | −9.2 | 0.005 | Down in cancer stem cells | Self renewal and survival of cancer stem cells |
| miR-30c | 1p34 | −5.6 | 1.16E−05 | Down in cancer stem cells | Self renewal and survival of cancer stem cells |
| miR-146b | 10q24.32 | 9.3 | 1.96E−05 | Up in thyroid, breast, pancreatic cancer | Suppresses KIT Inducible by TNF |
| miR-198 | 3q13 | 3.2 | 0.003 | Down in hepatocellular carcinoma up in prostate cancer | Not known |
| miR-181a1 | 1q31.32 | 6.2 | 0.006 | Up in pancreatic, thyroid and colon cancer | Target of p53 |
| miR-631 | 15.q24 | 4.7 | 0.0006 | Not known | Not known |
| miR-1 | 18q11 | 3.1 | 0.004 | Up in prostate cancer, down-regulated in other cancers | Suppresses E2F1 Synaptic signaling |
| miR-613 | 12p13 | 3.4 | 0.004 | Not known | Not known |
| miR-129-1 | 7q32.1 | 5.3 | 0.039 | Up in retinoblastoma, down-regulated in other cancers | Not known |
| miR-216 | 2p18.1 | 2.9 | 0.0017 | Down-regulated in pancreatic cancer | Not known |
| miR-499 | 20q11.22 | 3.7 | 0.0062 | Not know | Expressed in myocytes, involved in cell senescence |
| miR-564 | 3p21.31 | 9.4 | 1.84E−05 | Not known | Not known |