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. 2011 Feb 7;39(10):4192–4201. doi: 10.1093/nar/gkr050

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Fitness of CFT073 dinB yafP operon mutants. (A and B) Survival and fitness of dinB yafP operon mutants during in vitro competitions. (A) Competitive index of different mutants during batch culture competitions in LB: wild type (WT) and dinB (filled diamond); WT and dinB yafP (filled square); dinB yafP::FRT and dinB yafP::Cm^R (filled circle). The last competition was used as an evaluation of the cost of the Cm^R cassette. (B) Competitive index of different strains co-inoculated and incubated in LB for 5 days. Each point represents the mean (±SE) values from 3 independent experiments. (C and D) fitness of dinB yafP operon mutants during septicemia in the mouse model. (C) Competitive index of the WT and the different mutants, as well as measurements of Cm^R cassette cost during the competition. The latter was performed by competing yafP::FRT with yafP::Cm^R, and dinB yafP::FRT I with dinB yafP::Cm^R I mutants. (D) Competitive index of the WT and the dinB strain, which carried the pGB2 plasmid or the pGB2 bearing the functional dinB gene. Each point represents the mean (±SE) values from, at least 15 mice inoculated in at least three independent experiments. Asterisks show the competition for which the competitive index was significantly different (Wilcoxon test P < 0.05).