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. 2011 Jan 27;9(Suppl 1):S5. doi: 10.1186/1479-5876-9-S1-S5

Figure 1.

Figure 1

Overview of coreceptor use and cell tropism of different HIV-1 variants. Individual viral isolates are classified based on their ability to use CCR5 (R5 variants), CXCR4 (X4 variants) or both coreceptors (R5X4 variants). Bulk viral isolates capable of using both coreceptors are designated dual/mixed (D/M) as their quasispecies may contain any mixture of the various phenotypic variants. The cell tropism of each viral isolate is determined by the expression levels of CCR5 and CXCR4 on the various target cells.