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. 2011 Jun;137(6):533–548. doi: 10.1085/jgp.201110616

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© 2011 Geng et al.

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Figure 4. — Increasing side-chain volume has little effect on i_out in the presence of 2.5 M K⁺_i. (A and B) Representative records of outward currents through single channels at +200 mV with 2.5 M of intracellular K⁺ for hydrophobic (A) and uncharged hydrophilic (B) amino acid substitutions at positions 321/324. The dashed lines show current levels with alanine substitutions. (C and D) Plots of i_out in the presence of high 2.5-M K⁺_i versus voltage for hydrophobic (C) and uncharged hydrophilic (D) amino acid substitutions. Plots for valine and leucine substitution superimposed the plots for alanine substitution in C and are not shown. High K⁺_i negates the effect of side-chain volume on i_out (compare with Fig. 3 with 150 mM K⁺_i), as would be expected if larger side chains reduce the size of the entrance to the inner cavity.