Table II.
Estimated ORs and 95% CIs for four PGR polymorphisms and endometrial cancer risk
| rs number | Genotype | Pooled adjusted OR (95% CI)a | P-value | No. of cases | No. of controls | No. of cases | No. of controls | No. of cases | No. of controls |
| rs1042838 | ANECS/AOCS | SASBAC | SEARCH | ||||||
| V660L | 1220 | 1354 | 582 | 1538 | 1086 | 1591 | |||
| CC | 1.00 (ref) | 867 (71.1) | 933 (68.9) | 414 (71.1) | 1147 (74.6) | 765 (70.4) | 1123 (70.6) | ||
| CA | 1.00 (0.89–1.12) | 0.97 | 323 (26.5) | 383 (28.3) | 151 (25.9) | 361 (23.5) | 294 (27.1) | 434 (27.3) | |
| AA | 1.15 (0.83–1.60) | 0.40 | 30 (2.4) | 38 (2.8) | 17 (2.9) | 30 (2.0) | 27 (2.5) | 34 (2.1) | |
| Per allele | 1.02 (0.93–1.13) | 0.68 | |||||||
| rs10895068 | ANECS/AOCS | WISE | SEARCH | ||||||
| 331 G>A | 1213 | 1348 | 455 | 1701 | 1089 | 1593 | |||
| GG | 1.00 (ref) | 1058 (87.2) | 1185 (87.9) | 412 (90.5) | 1567 (92.1) | 966 (88.7) | 1392 (87.4) | ||
| AG | 1.00 (0.85–1.18) | 0.97 | 148 (12.2) | 160 (11.9) | 41 (9.0) | 121 (7.1) | 119 (10.9) | 192 (12.1) | |
| AA | 1.06 (0.51–2.21) | 0.88 | 7 (0.6) | 3 (0.2) | 2 (0.4) | 13 (0.8) | 4 (0.4) | 9 (0.6) | |
| Per allele | 1.01 (0.87–1.17) | 0.92 | |||||||
| rs11224561 | ANECS | LES | — | ||||||
| 3′ UTR tagSNP | 1188 | 997 | 205 | 648 | |||||
| GG | 1.00 (ref) | 838 (70.5) | 750 (75.2) | 145 (70.7) | 475 (73.3) | ||||
| AG | 1.24 (1.03–1.50) | 0.02 | 311 (26.2) | 225 (22.6) | 52 (25.4) | 162 (25.0) | |||
| AA | 2.10 (1.27–3.48) | 0.004 | 39 (3.3) | 22 (2.2) | 8 (3.9) | 11 (1.7) | |||
| Per allele | 1.31 (1.12–1.53)b | 0.001 | |||||||
| rs 471767 | ANECS | LES | - | ||||||
| 3′ UTR tagSNP | 1182 | 992 | 204 | 648 | |||||
| TT | 1 (ref) | 584 (49.4) | 487 (49.1) | 97 (47.5) | 300 (46.3) | ||||
| TC | 0.92 (0.78–1.09) | 0.32 | 485 (41.0) | 416 (41.9) | 82 (40.2) | 299 (46.1) | |||
| CC | 1.18 (0.89–1.57) | 0.26 | 113 (9.6) | 89 (9.0) | 25 (12.3) | 49 (7.6) | |||
| Per allele | 1.02 (0.90–1.15) | 0.78 | |||||||
a
Adjusted for age and study.
b
This equates to a 0.76-fold risk for the G allele. Risk estimates showed little difference when adjusted additionally for ethnicity (Caucasian versus other) e.g. (per allele OR 1.26; 95% CI 1.08–1.49, P = 0.005).