Fig. 4.

Inhibition of bladder cancer development by MSP-1. Female F344 rats were inoculated with AY-27 cells intravesically via a urethra catheter to initiate development of orthotopic bladder cancer. Oral administration of MSP-1 or vehicle (water) once daily was started 1 day after cancer cell inoculation and ended 3 weeks later. The number of rats per group varied from 11–29. (A) Initial (open bars) and final (filled bars) body weights. (B) Tumor weight was calculated by subtracting the average normal bladder weight from tumor-bearing bladder weight. *P < 0.05. Each value in A and B is mean ± SEM. (C) Percentage of bladder where the tumor invaded the muscle tissue.