Table 2.

Selected diffusion tensor imaging studies of mouse and rat brain or spinal cord.

Author	Applications	Resolution and imaging parameters	Ref.
Budde et al.	Axon and myelin injury in mouse spinal cords in experimental autoimmune encephalomyelitis	0.078 × 0.078 × 1 mm, in vivo, 4.7 Tesla spectrometer, spin echo, Δ= 25 ms, δ= 10 ms, b = 785 s/mm2. Total imaging time = 2 h	[37]
Sun et al.	Axon and myelin degeneration in mouse brains	0.117 × 0.117 × 0.5 mm, in vivo, 4.7 Tesla spectrometer, spin echo, Δ = 25 ms, δ = 10 ms, b = 768 s/mm2. Total imaging time = 3 h	[32]
Sizonenko et al.	Early cortical injury in neonatal rat after hypoxic ischemic injury	0.125 × 0.125 × 0.5 mm, in vivo, 4.7 Tesla spectrometer, spin echo, Δ = 25 ms, δ = 10 ms, b = 768 s/mm2. Total imaging time = 4 h	[57]
Ahren et al.	Axon and myelin pathology in mouse spinal cords in spontaneously acquired experimental allergic encephalomyelitis	0.02 × 0.02 × 0.3 mm, ex vivo, 11.7 Tesla spectrometer, spin echo, Δ = 7.4 ms, δ = 2 ms, b = 2000 s/mm2	[58]
Tyszka et al.	White matter abnormalities in myelin-deficit shiverer mouse brains	0.08 × 0.08 × 0.08 mm, ex vivo, 11.7 Tesla spectrometer, spin echo, Δ = 5 ms, δ = 3 ms, b = 1450 s/mm2	[12]
Mori et al.; Zhang et al.	Cortical and white matter development in embryonic mouse brains	0.08 × 0.08 × 0.08 mm, ex vivo, 9.4 Tesla spectrometer, spin echo, Δ = 12 ms, δ = 5 ms, b = 1200 s/mm2. Total imaging time = 24 h	[59,60]

Note that the diffusion times (Δ) in these experiments (−10 ms) are much shorter than in clinical diffusion tensor imaging (−80 ms) because of the short T₂ in high field.