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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Cancer Res. 2008 Dec 1;68(23):9996–10003. doi: 10.1158/0008-5472.CAN-08-2492

Figure 1.

Figure 1

A, morphology of osteosarcoma bone cell line MGC4-2 differed from MGRWV and MGLN at 90%confluence (top). MGC4-2 showed parallel, light-retractile, and flatter spindle cell alignment. No apparent cell morphologic difference was detected at a lower cell density (middle). Similar morphologic changes were also observed in a HS27A derivative, HS27AC4-2, after cellular interaction with C4-2 cells, compared with HS27ALN and HS27ARWV (bottom). B, giemsa-banded marker chromosomes of parental MG63, MG-derivatives (MGRWV, MGLN, and MGC4-2), and MG63 exposed to H2O2 (MGH2O2). Group a, (M1-M15) shared marker chromosomes between these cell lines. Group b, markers (m1 and m2) shared only by MGRWV and MGLN cell lines. Group c, six additional marker chromosomes (m1–m6) shared by MGC4-2 and MG63 cells exposed to H2O2. MGLN cells have only some of the group c markers. Nonclonal and unidentified altered chromosomes from each cell line are arranged on the far right (see text for group a, b, and c marker chromosomes).