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. 2011 Jun 1;6(6):e20459. doi: 10.1371/journal.pone.0020459

Figure 3. Degradation of α-actin is prevented by asp-4 and asp-6 RNAi in spaceflight and ground control (GC).

Figure 3

Dauer animals treated for 4 d with RNAi vector control (VC) developed to adulthood. In both GC and spaceflight conditions animals displayed major loss of muscle specific α-actin following lysis in the absence of lysosomal protease inhibitors. Treatment with asp-4 and asp-6 RNAi for 4 d in GC and spaceflight resulted in a preservation of α-actin levels. A, representative immunoblot; B, average non-normalised quantification of three Western blots against α-actin. ** denotes significant difference from both GC and spaceflight VC conditions (P<0.01).