Skip to main content
. 2011 Jun 1;6(6):e20644. doi: 10.1371/journal.pone.0020644

Table 2. Batch promoter analysis focused on peroxisome proliferator-activated receptor (PPAR) of the fifty top down-regulated genes in inguinal white adipose tissue of wild-type mice after β-carotene supplementation.

Gene Gene name p value fold-change putative PPRE
Npr3 natriuretic peptide receptor 3 0.00033 −4.18 Yes
Mosc1 MOCO sulphurase C-terminal domain containing 1 0.00234 −3.26 Yes
Dnmt3l DNA (cytosine-5-)-methyltransferase 3-like 0.00452 −3.14
Scd2 stearoyl-Coenzyme A desaturase 2 0.00606 −3.02 Yes
Lep Leptin 0.00106 −2.84
Rbp4 retinol binding protein 4, plasma 0.00030 −2.80 Yes
Pnpla3 patatin-like phospholipase domain containing 3 0.00098 −2.78
Dgat2 diacylglycerol O-acyltransferase 2 0.00166 −2.68 Yes
Slc2a5 solute carrier family 2 (facilitated glucose transporter), member 5 0.02198 −2.60
Fads3 fatty acid desaturase 3 0.00027 −2.52 Yes
Alb1 albumin 1 0.00058 −2.51 Yes
Mod1 malic enzyme, supernatant 0.00280 −2.46 Yes
Gsta3 glutathione S-transferase, alpha 3 0.00075 −2.46
Mogat2 monoacylglycerol O-acyltransferase 2 0.00408 −2.44 Yes
Fabp5 fatty acid binding protein 5, epidermal 0.00026 −2.37
Elovl6 ELOVL family member 6, elongation of long chain fatty acids (yeast) 0.01515 −2.36 Yes
Ela1 elastase 1, pancreatic 0.00155 −2.35 Yes
Cav1 caveolin, caveolae protein 1 0.00083 −2.35
Cspg3 chondroitin sulfate proteoglycan 3 0.02156 −2.33
Apol6 apolipoprotein L, 6 0.00167 −2.33 Yes
LOC676546 similar to monocyte to macrophage differentiation-associated 0.00024 −2.32 Yes
Sncg synuclein, gamma 0.00155 −2.32
Ppp2r5b protein phosphatase 2, regulatory subunit B (B56), beta isoform 0.00294 −2.31
Tkt Transketolase 0.01153 −2.31
Ntsr2 neurotensin receptor 2 0.00032 −2.31 Yes
Acss2 acyl-CoA synthetase short-chain family member 2 0.01181 −2.28 Yes
Mid1ip1 Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish)) 0.03037 −2.21 Yes
Retn Resistin 0.00282 −2.19
Lpgat1 lysophosphatidylglycerol acyltransferase 1 0.00024 −2.19 Yes
Lctl lactase-like 0.00010 −2.18 Yes
Slc6a13 solute carrier family 6 (neurotransmitter transporter, GABA), member 13 0.00394 −2.17
Comt catechol-O-methyltransferase 0.00946 −2.17
Thbd Thrombomodulin 0.01020 −2.17 Yes
Orm2 orosomucoid 2 0.00026 −2.14 Yes
Orm1 orosomucoid 1 0.00018 −2.13 Yes
Lrrc39 leucine rich repeat containing 39 0.00130 −2.12
Sc5d sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) 0.00095 −2.12
Fabp4 fatty acid binding protein 4, adipocyte 0.00690 −2.11 Yes
Lss lanosterol synthase 0.00103 −2.10
Odz4 odd Oz/ten-m homolog 4 (Drosophila) 0.00063 −2.10
Slc9a2 solute carrier family 9 (sodium/hydrogen exchanger), member 2 0.00214 −2.10 Yes
Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 0.00010 −2.10 Yes
Cpa2 carboxypeptidase A2, pancreatic 0.00157 −2.10
Timp4 tissue inhibitor of metalloproteinase 4 0.01792 −2.09
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.01228 −2.09 Yes
Adamts5 a disintegrin-like and metallopeptidase (reprolysin type) withthrombospondin type 1 motif, 5 (aggrecanase-2) 0.00287 −2.08
Kcnj14 potassium inwardly-rectifying channel, subfamily J, member 14 0.00022 −2.07
Slc16a12 solute carrier family 16 (monocarboxylic acid transporters), member 12 0.00221 −2.07 Yes
Dbi diazepam binding inhibitor 0.00384 −2.06 Yes
Fasn fatty acid synthase 0.00220 −2.06

Batch promoter analysis was performed with Eldorado coupled to matinspector (Genomatix Suite). Yes in the right column indicates the presence in the corresponding gene promoter of a putative PPAR response element (PPRE) with at least 85% homology with the matrix similarity defined by Genomatix.