Table 2. Batch promoter analysis focused on peroxisome proliferator-activated receptor (PPAR) of the fifty top down-regulated genes in inguinal white adipose tissue of wild-type mice after β-carotene supplementation.
Gene | Gene name | p value | fold-change | putative PPRE |
Npr3 | natriuretic peptide receptor 3 | 0.00033 | −4.18 | Yes |
Mosc1 | MOCO sulphurase C-terminal domain containing 1 | 0.00234 | −3.26 | Yes |
Dnmt3l | DNA (cytosine-5-)-methyltransferase 3-like | 0.00452 | −3.14 | |
Scd2 | stearoyl-Coenzyme A desaturase 2 | 0.00606 | −3.02 | Yes |
Lep | Leptin | 0.00106 | −2.84 | |
Rbp4 | retinol binding protein 4, plasma | 0.00030 | −2.80 | Yes |
Pnpla3 | patatin-like phospholipase domain containing 3 | 0.00098 | −2.78 | |
Dgat2 | diacylglycerol O-acyltransferase 2 | 0.00166 | −2.68 | Yes |
Slc2a5 | solute carrier family 2 (facilitated glucose transporter), member 5 | 0.02198 | −2.60 | |
Fads3 | fatty acid desaturase 3 | 0.00027 | −2.52 | Yes |
Alb1 | albumin 1 | 0.00058 | −2.51 | Yes |
Mod1 | malic enzyme, supernatant | 0.00280 | −2.46 | Yes |
Gsta3 | glutathione S-transferase, alpha 3 | 0.00075 | −2.46 | |
Mogat2 | monoacylglycerol O-acyltransferase 2 | 0.00408 | −2.44 | Yes |
Fabp5 | fatty acid binding protein 5, epidermal | 0.00026 | −2.37 | |
Elovl6 | ELOVL family member 6, elongation of long chain fatty acids (yeast) | 0.01515 | −2.36 | Yes |
Ela1 | elastase 1, pancreatic | 0.00155 | −2.35 | Yes |
Cav1 | caveolin, caveolae protein 1 | 0.00083 | −2.35 | |
Cspg3 | chondroitin sulfate proteoglycan 3 | 0.02156 | −2.33 | |
Apol6 | apolipoprotein L, 6 | 0.00167 | −2.33 | Yes |
LOC676546 | similar to monocyte to macrophage differentiation-associated | 0.00024 | −2.32 | Yes |
Sncg | synuclein, gamma | 0.00155 | −2.32 | |
Ppp2r5b | protein phosphatase 2, regulatory subunit B (B56), beta isoform | 0.00294 | −2.31 | |
Tkt | Transketolase | 0.01153 | −2.31 | |
Ntsr2 | neurotensin receptor 2 | 0.00032 | −2.31 | Yes |
Acss2 | acyl-CoA synthetase short-chain family member 2 | 0.01181 | −2.28 | Yes |
Mid1ip1 | Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish)) | 0.03037 | −2.21 | Yes |
Retn | Resistin | 0.00282 | −2.19 | |
Lpgat1 | lysophosphatidylglycerol acyltransferase 1 | 0.00024 | −2.19 | Yes |
Lctl | lactase-like | 0.00010 | −2.18 | Yes |
Slc6a13 | solute carrier family 6 (neurotransmitter transporter, GABA), member 13 | 0.00394 | −2.17 | |
Comt | catechol-O-methyltransferase | 0.00946 | −2.17 | |
Thbd | Thrombomodulin | 0.01020 | −2.17 | Yes |
Orm2 | orosomucoid 2 | 0.00026 | −2.14 | Yes |
Orm1 | orosomucoid 1 | 0.00018 | −2.13 | Yes |
Lrrc39 | leucine rich repeat containing 39 | 0.00130 | −2.12 | |
Sc5d | sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) | 0.00095 | −2.12 | |
Fabp4 | fatty acid binding protein 4, adipocyte | 0.00690 | −2.11 | Yes |
Lss | lanosterol synthase | 0.00103 | −2.10 | |
Odz4 | odd Oz/ten-m homolog 4 (Drosophila) | 0.00063 | −2.10 | |
Slc9a2 | solute carrier family 9 (sodium/hydrogen exchanger), member 2 | 0.00214 | −2.10 | Yes |
Aldh1a7 | aldehyde dehydrogenase family 1, subfamily A7 | 0.00010 | −2.10 | Yes |
Cpa2 | carboxypeptidase A2, pancreatic | 0.00157 | −2.10 | |
Timp4 | tissue inhibitor of metalloproteinase 4 | 0.01792 | −2.09 | |
Slc2a4 | solute carrier family 2 (facilitated glucose transporter), member 4 | 0.01228 | −2.09 | Yes |
Adamts5 | a disintegrin-like and metallopeptidase (reprolysin type) withthrombospondin type 1 motif, 5 (aggrecanase-2) | 0.00287 | −2.08 | |
Kcnj14 | potassium inwardly-rectifying channel, subfamily J, member 14 | 0.00022 | −2.07 | |
Slc16a12 | solute carrier family 16 (monocarboxylic acid transporters), member 12 | 0.00221 | −2.07 | Yes |
Dbi | diazepam binding inhibitor | 0.00384 | −2.06 | Yes |
Fasn | fatty acid synthase | 0.00220 | −2.06 |
Batch promoter analysis was performed with Eldorado coupled to matinspector (Genomatix Suite). Yes in the right column indicates the presence in the corresponding gene promoter of a putative PPAR response element (PPRE) with at least 85% homology with the matrix similarity defined by Genomatix.