Table 2. Genotyping and allele frequency of ORAI1 tSNP in HLA-B27(+) or HLA-B27(-) with ankylosing spondylitis (AS) and controls.
| Genotype | HLA-B27(+) (n = 315) (%) | HLA-B27(-) (n = 46) (%) | Control Subjects (n = 379) (%) | Recessive Odds ratio† | Recessive P Value† | Recessive Odds ratio‡ | Recessive P Value‡ | |
| rs12320939 | TT | 68 (22.2) | 15 (32.6) | 90 (26.1) | 0.89 | 0.511 | 1.68 | 0.138 |
| GT | 142 (46.4) | 22 (47.8) | 165 (47.8) | |||||
| GG | 96 (31.4) | 9 (19.6) | 90 (26.1) | |||||
| rs12313273 | CC | 34 (10.9) | 7 (15.6) | 20 (5.7) | 2.11 | 0.012 | 3.32 | 0.015 |
| CT | 116 (37.3) | 18 (40.0) | 148 (41.8) | |||||
| TT | 161 (51.8) | 20 (44.4) | 186 (52.5) | |||||
| rs7135617 | TT | 72 (23.2) | 6 (13.7) | 60 (17.0) | 1.70 | 0.008 * | 0.90 | 0.817 |
| GT | 139 (44.9) | 21 (47.7) | 164 (46.6) | |||||
| GG | 99 (31.9) | 17 (38.6) | 128 (36.4) | |||||
| rs6486795 | CC | 50 (16.1) | 10 (22.2) | 54 (15.6) | 1.13 | 0.581 | 1.91 | 0.108 |
| CT | 126 (40.7) | 21 (46.7) | 159 (45.8) | |||||
| TT | 134 (43.2) | 14 (31.1) | 134 (38.6) | |||||
| rs712853 | CC | 25 (8.1) | 1 (2.2) | 59 (16.2) | 0.46 | 0.002 * | 0.13 | 0.045 |
| CT | 109 (35.3) | 24 (52.2) | 153 (42.0) | |||||
| TT | 175 (56.6) | 21 (45.6) | 152 (41.8) |
*Significant (P<0.01) values are in bold.
†Adjusted the effects of age and sex for HLA-B27 positive patients compared with controls.
‡Adjusted the effects of age and sex for HLA-B27 negative patients compared with controls.