Table 2.
Echocardiographic characteristics of the study cohort (n = 74) before HSCT and 1-year post HSCT
| Echocardiographic characteristic | Before HSCT Mean ± s.d. | 1-year post HSCT Mean ± s.d. | P-value |
|---|---|---|---|
| Timing of echocardiogram relative to HSCT (months) | –0.7 ± 0.5 | 12.8 ± 1.6 | |
| Heart rate, mean (n = 67) | 94.6 ± 20.4 | 89.7 ± 20.0 | 0.05 |
| Systolic BP (mm Hg), mean (n = 64) | 104.7 ± 12.7 | 104.8 ± 15.4 | 0.98 |
| Diastolic BP (mm Hg), mean (n = 64) | 56.3 ± 10.2 | 59.4 ± 10.3 | 0.08 |
| Parameters of systolic function | |||
| LVEF (%), mean (n = 70) | 61.2 ± 5.0 | 60.6 ± 5.4 | 0.45 |
| LV fractional shortening (z-score), (n = 68) | –0.72 ± 1.20 | –1.08 ± 1.31 | 0.06 |
| Vcfc (z-score), (n = 64) | –0.02 ± 1.80 | –0.62 ± 1.54 | 0.03 |
| LV end systolic stress (z-score), (n = 60) | 0.64 ± 1.84 | 0.72 ± 1.77 | 0.78 |
| LV contractility (z-score), (n = 60) | 0.39 ± 1.40 | –0.22 ± 1.09 | 0.01 |
| Stress-shortening index (z-score), (n = 60) | –0.08 ± 1.11 | –0.41 ± 1.07 | 0.09 |
| LV mass (g), (n = 66) | 69.7 ± 43.8 | 66.6 ± 39.1 | 0.22 |
| LV mass/volume ratio, (n = 67) | 0.89 ± 0.16 | 0.86 ± 0.16 | 0.20 |
| LV EDD (cm), (n = 68) | 4.1 ± 0.9 | 4.1 ± 0.8 | 0.73 |
| LV PWED (cm), (n = 66) | 0.63 ± 0.16 | 0.65 ± 0.16 | 0.45 |
| IVS ED (cm), (n = 56) | 0.67 ± 0.17 | 0.66 ± 0.18 | 0.94 |
| Parameters of diastolic function | |||
| TDI Derived Velocities | |||
| Lateral mitral annulus E′ (cm/s), (n = 60) | 16.7 ± 3.7 | 15.0 ± 3.5 | 0.003 |
| Lateral mitral annulus A′ (cm/s), (n = 56) | 6.4 ± 2.1 | 6.3 ± 2.0 | 0.87 |
| Lateral mitral annulus S′ (cm/s), (n = 60) | 9.3 ± 2.5 | 8.7 ± 2.2 | 0.09 |
| Septal E′ (cm/s), (n = 60) | 11.4 ± 2.0 | 10.9 ± 2.1 | 0.10 |
| Septal A′ (cm/s), (n = 57) | 6.7 ± 1.8 | 6.2 ± 1.9 | 0.18 |
| Septal S′ (cm/s), (n = 60) | 7.5 ± 1.5 | 7.2 ± 1.2 | 0.10 |
| Lateral tricuspid annulus E′ (cm/s), (n = 57) | 14.3 ± 3.5 | 12.5 ± 2.7 | 0.002 |
| Lateral tricuspid annulus A′ (cm/s), (n = 47) | 10.4 ± 3.8 | 10.1 ± 3.2 | 0.59 |
| Lateral tricuspid annulus S′ (cm/s), (n = 58) | 12.4 ± 2.5 | 11.9 ± 2.2 | 0.25 |
| LV flow propagation (cm/s), (n = 51) | 70.9 ± 23.6 | 61.2 ± 20.8 | 0.04 |
| Mitral A wave time (ms), (n = 27) | 110.4 ± 24.4 | 108.2 ± 20.4 | 0.73 |
| Mitral E wave peak vel (m/s), (n = 42) | 0.87 ± 0.23 | 0.83 ± 0.21 | 0.34 |
| Mitral A wave peak vel (m/s), (n = 37) | 0.50 ± 0.12 | 0.49 ± 0.13 | 0.56 |
| Mitral E decel time (ms), (n = 38) | 135.8 ± 42.2 | 126.3 ± 40.8 | 0.37 |
Abbreviations: BP = blood pressure; Decel = deceleration; EDD = end-diastolic dimension; HSCT = hematopoietic stem cell transplant; IVSED = end-diastolic interventricular septal thickness; LVEF = left-ventricular ejection fraction; LV = left-ventricular; PWED = end-diastolic posterior wall thickness; TDI = tissue Doppler imaging; Vcfc = rate-corrected velocity of fiber shortening; Vel = velocity.
All comparisons made by paired Student's t-test. Comparisons with P-values <0.05 are highlighted in bold text.