Table 3.
Comparison of pre-HSCT echocardiographic characteristics of HSCT recipients who died before 1 year compared with the study cohort, all of whom survived to 1 year
| Echocardiographic characteristic |
Study cohort |
Died before 1 year |
P-value | ||
|---|---|---|---|---|---|
| n | Mean ± s.d. | n | Mean ± s.d. | ||
| Heart rate, mean | 69 | 96.1 ± 22.1 | 21 | 101.2 ± 28.1 | 0.38 |
| Systolic BP (mm Hg), mean | 68 | 104.1 ± 13.5 | 21 | 103.0 ± 10.3 | 0.73 |
| Diastolic BP (mm Hg), mean | 68 | 56.2 ± 11.3 | 21 | 60.7 ± 10.2 | 0.11 |
| Parameters of systolic function | |||||
| LVEF (%), mean | 70 | 61.2 ± 5.0 | 21 | 57.3 ± 5.7 | 0.003 |
| LV fractional shortening (z-score) | 71 | –0.72 ± 1.18 | 21 | –1.27 ± 1.10 | 0.06 |
| Vcfc (z-score) | 68 | –0.01 ± 1.77 | 19 | –0.92 ± 2.11 | 0.05 |
| LV end systolic stress (z-score) | 67 | 0.66 ± 1.90 | 19 | 1.17 ± 2.01 | 0.32 |
| LV contractility (z-score) | 67 | 0.48 ± 1.41 | 18 | –0.06 ± 1.52 | 0.16 |
| Stress-shortening Index (z-score) | 67 | 0.02 ± 1.12 | 18 | –0.37 ± 1.29 | 0.21 |
| LV mass (g) | 68 | 69.5 ± 44.1 | 21 | 65.6 ± 39.9 | 0.72 |
| LV mass/volume ratio | 69 | 0.89 ± 0.17 | 21 | 0.92 ± 0.25 | 0.54 |
| LV EDD (cm) | 71 | 4.1 ± 0.9 | 21 | 3.9 ± 1.0 | 0.40 |
| LV PWED (cm) | 71 | 0.63 ± 0.16 | 20 | 0.60 ± 0.20 | 0.98 |
| IVS ED (cm) | 63 | 0.62 ± 0.12 | 15 | 0.60 ± 0.10 | 0.44 |
| Parameters of diastolic function | |||||
| TDI-derived velocities | |||||
| Lateral mitral annulus E′ (cm/s) | 63 | 16.5 ± 3.8 | 16 | 14.0 ± 3.3 | 0.02 |
| Lateral mitral annulus A′ (cm/s) | 61 | 6.4 ± 2.0 | 14 | 6.7 ± 2.4 | 0.62 |
| Lateral mitral annulus S′ (cm/s) | 63 | 9.2 ± 2.6 | 16 | 8.9 ± 2.7 | 0.71 |
| Septal E′ (cm/s) | 63 | 11.3 ± 2.1 | 15 | 10.5 ± 3.0 | 0.22 |
| Septal A′ (cm/s) | 61 | 6.7 ± 1.9 | 12 | 6.1 ± 2.8 | 0.35 |
| Septal S′ (cm/s) | 63 | 7.4 ± 1.5 | 15 | 7.6 ± 2.6 | 0.76 |
| Lateral tricuspid annulus E′ (cm/s) | 60 | 14.2 ± 3.6 | 13 | 14.3 ± 4.7 | 0.98 |
| Lateral tricuspid annulus A′ (cm/s) | 52 | 10.4 ± 3.7 | 9 | 11.3 ± 7.1 | 0.55 |
| Lateral tricuspid annulus S′ (cm/s) | 61 | 12.3 ± 2.6 | 13 | 12.2 ± 2.8 | 0.89 |
| LV flow propagation (cm/s) | 56 | 70.5 ± 23.1 | 14 | 59.8 ± 18.2 | 0.11 |
| Mitral A wave time (ms) | 39 | 108.9 ± 22.6 | 10 | 110.9 ± 28.3 | 0.82 |
| Mitral E wave peak vel (m/s) | 55 | 0.88 ± 0.24 | 16 | 0.81 ± 0.14 | 0.29 |
| Mitral A wave peak vel (m/s) | 46 | 0.50 ± 0.12 | 14 | 0.49 ± 0.25 | 0.81 |
| Mitral E decel time (ms) | 49 | 132.7 ± 41.0 | 10 | 140.1 ± 32.5 | 0.59 |
Abbreviations: BP = blood pressure; Decel = deceleration; EDD = end-diastolic dimension; HSCT = hematopoietic stem cell transplant; IVS ED = end-diastolic interventricular septal thickness; LVEF = left-ventricular ejection fraction; LV = left-ventricular; PWED = end-diastolic posterior wall thickness; TDI = tissue Doppler imaging; Vcfc = rate-corrected velocity of fiber shortening; Vel = velocity.
All comparisons made by paired Student's t-test. Comparisons with P-values <0.05 are highlighted in bold text.