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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Arthritis Rheum. 2011 Jun;63(6):1603–1612. doi: 10.1002/art.30271

Figure 3. Arthritis depends primarily on JNK1 in bone marrow-derived cells.

Figure 3

A) WT and Jnk1−/− mice (n=8/group) were irradiated and reconstituted with Jnk1−/− or WT bone marrow as indicated. AIA was induced 8 weeks after bone marrow reconstitution and mice were analyzed 10 days later. One knee from each mouse was prepared for histologic scoring with H&E and safranin O staining. Shown are average inflammation, erosion, and cartilage damage scores ± SEM. B) Whole joint RNA was extracted and amounts of mRNAs were analyzed by qPCR. Cytokine mRNA expression decreased in mice reconstituted with Jnk1−/− bone marrow. Results are expressed as means ± SEM for 5 mice/group.