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. Author manuscript; available in PMC: 2012 Jun 1.

Published in final edited form as: Arthritis Rheum. 2011 Jun;63(6):1613–1625. doi: 10.1002/art.30311

Catabolic and anabolic networks regulated by GTW in MIA. (A) Intensity plot of 142 genes that are a known set of arthritis-associated genes in Ingenuity Knowledge Database, and more than 2-fold up (red) or down (green) regulated in MIA21 (see Supplemental Data for details). (B–E) IPA generated networks of: (B) catabolic genes that are downregulated by GTW in MIA+GTW1-21 showing suppression of genes involved in acute and chronic inflammatory/immune responses via the suppression of NF-κB activity; (C) anabolic genes that are upregulated by exercise in MIA+GTW1-21 showing induction of Sox9 and TGF-β that in turn may upregulate the expression of matrix associated genes; (D) catabolic gene regulation by GTW in MIA+GTW5-21 showing partial suppression of genes involved in acute and chronic immune responses; (E) anabolic gene regulation by GTW in MIA+GTW5-21 showing suppression of Sox9 and TGF-β and number of matrix proteins that may limit its ability to repair cartilage. Red, green, and white colors represent upregulation, downregulation and no regulation, respectively. The shading of colors represents dark, greater changes to light lesser changes. Symbols are: cytokine/growth factor, phosphatase, Transcription regulator, translation regulator, transmembrane receptor, complex group, enzyme, G protein coupled receptor, kinase, peptidase, and other.

Inline graphic — Catabolic and anabolic networks regulated by GTW in MIA. (A) Intensity plot of 142 genes that are a known set of arthritis-associated genes in Ingenuity Knowledge Database, and more than 2-fold up (red) or down (green) regulated in MIA21 (see Supplemental Data for details). (B–E) IPA generated networks of: (B) catabolic genes that are downregulated by GTW in MIA+GTW1-21 showing suppression of genes involved in acute and chronic inflammatory/immune responses via the suppression of NF-κB activity; (C) anabolic genes that are upregulated by exercise in MIA+GTW1-21 showing induction of Sox9 and TGF-β that in turn may upregulate the expression of matrix associated genes; (D) catabolic gene regulation by GTW in MIA+GTW5-21 showing partial suppression of genes involved in acute and chronic immune responses; (E) anabolic gene regulation by GTW in MIA+GTW5-21 showing suppression of Sox9 and TGF-β and number of matrix proteins that may limit its ability to repair cartilage. Red, green, and white colors represent upregulation, downregulation and no regulation, respectively. The shading of colors represents dark, greater changes to light lesser changes. Symbols are: cytokine/growth factor, phosphatase, Transcription regulator, translation regulator, transmembrane receptor, complex group, enzyme, G protein coupled receptor, kinase, peptidase, and other.