Table 1.
GTW-induced differential expression of salient genes in MIA afflicted cartilage.
|
Cluster I | ||
|---|---|---|
| Gene | MIA+GTW 1-21 (%MIA21) | MIA+GTW 5-21 (%MIA21) |
| Alox5ap | −206 | −119 |
| Calcr | −183 | −136 |
| Fcgr1a | −182 | −101 |
| Tlr7 | −179 | +115 |
| C3 | −178 | −104 |
| Hla-dmb | −176 | +130 |
| Cd53 | −169 | −122 |
| Aspn | −166 | +148 |
| Ctsg | −126 | +106 |
| Il1rl1 | −124 | +156 |
|
Cluster II | ||
|---|---|---|
| Gene | MIA+GTW1-21 (%MIA21) | MIA+GTW 5-21 (%MIA21) |
| Cd84 | −161 | −133 |
| Il18 | −149 | −102 |
| Mmp12 | −144 | +130 |
| Cd44 | −140 | −104 |
| Tnfsf13 | −140 | −103 |
| Adamts7 | −136 | −112 |
| Adamts4 | −118 | −185 |
| Ccl9 | −117 | +125 |
| Ccr1 | −112 | −117 |
| Mmp19 | −110 | −121 |
|
Cluster III | ||
|---|---|---|
| Gene | MIA+ GTW1-21 (%MIA21) | MIA+GTW5-21 (%MIA21) |
| Clec4d | −209 | +103 |
| Alox5 | −193 | −126 |
| Vcam1 | −171 | −102 |
| Adam23 | −138 | +103 |
| Crlf1 | −131 | −126 |
| Cdh13 | −125 | −139 |
| Postn | −122 | +123 |
| C1s | −120 | −142 |
| Serpine1 | −119 | +101 |
| Cd14 | −115 | −152 |
|
Cluster IV | ||
|---|---|---|
| Gene | MIA+ GTW1-21 (%MIA21) | MIA+GTW5-21 (%MIA21) |
| Cilp | +445 | −104 |
| Cytl1 | +226 | −107 |
| Cilp2 | +210 | −156 |
| Hapln3 | +158 | +103 |
| Acan | +152 | −110 |
| Sox9 | +150 | −123 |
| Gdf10 | +140 | −176 |
| Igf2 | +139 | +136 |
| Casr | +139 | −219 |
| Chst3 | +114 | −128 |
|
Cluster V | ||
|---|---|---|
| Gene | MIA+GTW1-21 (%MIA21) | MIA+GTW5-21 (%MIA21) |
| Col9a1 | +1102 | +341 |
| Matn3 | +979 | +322 |
| Frzb | +761 | +129 |
| Mia | +381 | +229 |
| Col2a1 | +324 | +109 |
| Chad | +287 | −101 |
| Hapln1 | +277 | +108 |
| Col11a2 | +264 | +126 |
| Vit | +251 | −101 |
| Prg4 | +165 | −140 |