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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Arthritis Rheum. 2011 Jun;63(6):1552–1561. doi: 10.1002/art.30260

Figure 1.

Figure 1

DQ6.4 mice are susceptible to develop collagen-induced arthritis. A) Expression of DQ in transgenic DQ6.1 and DQ6.4 mice. Both DQ6.1 and DQ6.4 mice showed positive staining with conjugated antibodies IVD12 (anti-DQ) and L227 (anti-DQ6) antibodies while Aβo mice were negative. N=4 B) Incidence and C) severity of arthritis in transgenic and control FVB mice (10–12 mice in each group). D) Anti-collagen antibodies in mice immunized with type II collagen, measured by ELISA. E) DQ6.4 mice generate a more robust in vitro T cell response to CII compared to DQ6.1 mice (3–4 mice in each group). In vitro T cell response was measured in LNCs isolated from CII-primed mice. F) The CII-specific response was CD4-mediated and DQ-restricted as tested by inhibition studies using anti-DQ (IVD12) and anti-CD4 (GK1.5) antibodies. G) In vitro recall response to CII-derived peptides in transgenic mice primed with individual peptides.