Table 2.
Polymorphism in DQ6 molecules and peptide binding pockets in various DQ haplotypes
| A. Amino Acid Polymorphisms outside anchoring pockets* | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Alpha chain | 15 | 22+ | 23 | 38 | 42 | 44 | 45 | 47 | 49 | 50 | 53 | 58 | 61 | 63 | 77 | 126 | 127 | 172 | 184 | 204 |
| DQA1*0102 | F | Y | T | R | A | R | W | E | S | K | G | G | R | M | Y | Q | S | Q | A | M |
| DQA1*0103 | F | F | T | K | A | R | W | E | S | K | G | G | R | M | Y | H | A | Q | A | V |
| DQA1*0301 | S | Y | S | R | V | Q | L | L | R | R | R | F | T | I | S | H | S | E | T | V |
| Beta chain | 3 | 53 | 55 | 66 | 84 | 87 | 125 | 130 | 140 | 167 | ||||||||||
| DQB1*0302 | S | L | P | E | Q | L | A | R | T | R | ||||||||||
| DQB1*0601 | P | Q | R | D | E | F | G | R | A | H | ||||||||||
| DQB1*0604 | S | Q | R | E | E | Y | G | Q | A | R | ||||||||||
| B. Amino Acid Polymorphisms within anchoring Pockets | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DQA1/DQB1 | P1 | P4 | P6 | P7 | P9 | ||||||||||
| α9, α31, α52, β86 | β13, β26, | α66, β9, β30 | β67 | α73, β9, β37, β38, β57 | |||||||||||
| *0301/*0302 | Y | E | R | E | G | L | L | Y | Y | V | V | Y | Y | A | A |
| *0103/*0601 | C | Q | G | A | A | Y | A | L | Y | I | M | L | D | V | D |
| *0103/*0604 | C | Q | G | G | G | L | A | Y | H | V | M | Y | Y | A | V |