Table 1.
Genetic association between IL2/IL21 in European-derived lupus patients and controls.
| Associated | Frequency | 95% CI | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Marker | Position | Gene | Function | Allele | Cases | Controls | OR | LL | UL | P Value |
| rs13119723 | 123437763 | KIAA1109 | Intron | A | 0.88 (6633:935) | 0.87 (5840:912) | 1.11 | 1.01 | 1.22 | 0.04 |
| rs1127348 | 123500310 | KIAA1109 | Coding | G | 0.23 (1843:6073) | 0.21 (1507:5581) | 1.12 | 1.04 | 1.21 | 0.003 |
| rs6814233 | 123533582 | ADAD1 | Intron | C | 0.70 (5421:2367) | 0.70 (4826:2122) | 1.01 | 0.94 | 1.08 | 0.85 |
| rs17388568 | 123548812 | ADAD1 | Intron | A | 0.28 (2168:5610) | 0.26 (1795:5157) | 1.11 | 1.03 | 1.19 | 0.005 |
| rs12499753 | 123552627 | ADAD1 | Intron | G | 0.34 (2587:5145) | 0.32 (2205:4737) | 1.08 | 1.01 | 1.16 | 0.029 |
| rs6827839 | 123558465 | ADAD1 | Intron | A | 0.40 (3056:4536) | 0.40 (2678:4096) | 1.03 | 0.96 | 1.10 | 0.38 |
| rs11732095 | 123567795 | ADAD1 | Intron | A | 0.91 (7205:725) | 0.90 (6346:714) | 1.12 | 1.00 | 1.25 | 0.044 |
| rs2069779 | 123593347 | IL2 | Intron | A | 0.08 (586:7002) | 0.07 (444:6324) | 1.19 | 1.05 | 1.36 | 0.0071 |
| rs4833248 | 123599855 | IL2 | Flanking 5' UTR | G | 0.70 (5355:2345) | 0.69 (4754:2108) | 1.01 | 0.94 | 1.09 | 0.73 |
| rs10857092 | 123608669 | IL2 | Flanking 5' UTR | A | 0.07 (519:7433) | 0.06 (456:6632) | 1.02 | 0.89 | 1.16 | 0.82 |
| rs6814718 | 123642766 | IL2 | Flanking 5' UTR | G | 0.73 (5779:2113) | 0.71 (4975:2073) | 1.14 | 1.06 | 1.22 | 0.0003 |
| rs4833834 | 123685801 | IL21 | Flanking 3' UTR | G | 0.10 (816:7070) | 0.10 (725:6309) | 1.00 | 0.90 | 1.12 | 0.94 |
| rs13140464 | 123719195 | IL21 | Flanking 3' UTR | C | 0.86 (6770:1108) | 0.85 (5917:1087) | 1.12 | 1.03 | 1.22 | 0.013 |
| rs6822844 | 123728871 | IL21 | Flanking 3' UTR | C | 0.86 (6829:1121) | 0.85 (5984:1100) | 1.12 | 1.02 | 1.23 | 0.014 |
| rs6835457 | 123730576 | IL21 | Flanking 3' UTR | A | 0.68 (5433:2507) | 0.65 (4629:2453) | 1.15 | 1.07 | 1.23 | 6.8 ×10−5 |
| rs975404 | 123740742 | IL21 | Flanking 3' UTR | A | 0.65 (5169:2745) | 0.63 (4443:2571) | 1.09 | 1.02 | 1.17 | 0.012 |
| rs907715 | 123754503 | IL21 | Intron | G | 0.69 (5374:2462) | 0.66 (4590:2416) | 1.15 | 1.07 | 1.23 | 7.2 ×10−5 |
| rs4833837 | 123756413 | IL21 | Coding | G | 0.32 (2508:5412) | 0.30 (2093:4967) | 1.10 | 1.03 | 1.18 | 0.0074 |
| rs2221903 | 123758362 | IL21 | Intron | G | 0.32 (2474:5382) | 0.30 (2063:4935) | 1.10 | 1.03 | 1.18 | 0.0079 |
| rs13143866 | 123760208 | IL21 | Intron | G | 0.74 (5523:1985) | 0.71 (4733:1921) | 1.13 | 1.05 | 1.22 | 0.0012 |
| rs4295278 | 123766991 | IL21 | Flanking 5' UTR | A | 0.95 (7563:375) | 0.95 (6734:338) | 1.01 | 0.87 | 1.18 | 0.87 |
| rs4833838 | 123770148 | IL21 | Flanking 5' UTR | A | 0.97 (7690:258) | 0.97 (6841:245) | 1.07 | 0.89 | 1.28 | 0.47 |
| rs6840978 | 123774157 | IL21 | Flanking 5' UTR | G | 0.82 (6553:1399) | 0.81 (5714:1366) | 1.12 | 1.03 | 1.22 | 0.0072 |
| rs13137822 | 123776686 | IL21 | Flanking 5' UTR | C | 0.45 (3498:4334) | 0.43 (3043:3971) | 1.05 | 0.99 | 1.12 | 0.12 |
| rs2137497 | 123777704 | IL21 | Flanking 5' UTR | C | 0.58 (4564:3252) | 0.58 (4035:2917) | 1.01 | 0.95 | 1.08 | 0.66 |
| rs2390352 | 123777780 | IL21 | Flanking 5' UTR | A | 0.96 (7530:336) | 0.95 (6691:337) | 1.13 | 0.97 | 1.32 | 0.13 |
| rs7694252 | 123780886 | IL21 | Flanking 5' UTR | A | 0.71 (5543:2277) | 0.70 (4879:2071) | 1.03 | 0.96 | 1.11 | 0.37 |
| rs6419221 | 123783569 | IL21 | Flanking 5' UTR | G | 0.64 (5048:2806) | 0.64 (4503:2571) | 1.03 | 0.96 | 1.10 | 0.43 |
| rs1533236 | 123783908 | IL21 | Flanking 5' UTR | G | 0.51 (4060:3896) | 0.50 (3541:3551) | 1.04 | 0.98 | 1.11 | 0.18 |
| rs10518400 | 123801876 | IL21 | Flanking 5' UTR | A | 0.08 (600:7354) | 0.07 (512:6576) | 1.05 | 0.93 | 1.18 | 0.45 |
| rs9307509 | 123807941 | IL21 | Flanking 5' UTR | T | 0.91 (6673:639) | 0.91 (5947:617) | 1.08 | 0.96 | 1.22 | 0.18 |
| rs6837455 | 123808392 | IL21 | Flanking 5' UTR | C | 0.15 (1189:6755) | 0.15 (1036:6050) | 1.03 | 0.94 | 1.13 | 0.55 |
| rs13147359 | 123816621 | IL21 | Flanking 5' UTR | A | 0.97 (7691:229) | 0.97 (6847:209) | 1.02 | 0.85 | 1.24 | 0.80 |
| rs309414 | 123840362 | BBS12 | Flanking 3' UTR | A | 0.39 (2974:4606) | 0.38 (2619:4271) | 1.05 | 0.98 | 1.13 | 0.13 |
| rs17006053 | 123849111 | BBS12 | Flanking 3' UTR | C | 0.76 (5958:1836) | 0.76 (5275:1657) | 1.02 | 0.94 | 1.10 | 0.62 |
OR, odds ratio; LL, lower limit; UL, upper limit; CI, confidence interval. The numbers between parenthesis represent the number of risk (associated) and protective (non-associated) alleles, respectively.