Table 3.
Genetic association between IL2/IL21 in African-American lupus patients and controls.
| Associated | Frequency | 95% CI | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Marker | Position | Gene | Function | Allele | Cases | Controls | OR | LL | UL | P Value |
| rs13151961 | 123334952 | KIAA1109 | Intron | A | 0.96 (2475:103) |
0.96 (3188:134) |
1.01 | 0.78 | 1.31 | 0.94 |
| rs13119723 | 123437763 | KIAA1109 | Intron | G | 0.03 (75:2735) |
0.02 (79:3427) |
1.19 | 0.86 | 1.64 | 0.29 |
| rs1127348 | 123500310 | KIAA1109 | Coding | A | 0.97 (2744:82) |
0.96 (3403:127) |
1.25 | 0.62 | 1.66 | 0.12 |
| rs6814233 | 123533582 | ADAD1 | Intron | A | 0.08 (212:2602) |
0.07 (251:3247) |
1.05 | 0.87 | 1.27 | 0.59 |
| rs17388568 | 123548812 | ADAD1 | Intron | G | 0.96 (2700:124) |
0.95 (3334:190) |
1.24 | 0.98 | 1.56 | 0.068 |
| rs12499753 | 123552627 | ADAD1 | Intron | A | 0.90 (2541:283) |
0.90 (3156:372) |
1.06 | 0.90 | 1.25 | 0.50 |
| rs6827839 | 123558465 | ADAD1 | Intron | A | 0.63 (1769:1035) |
0.61 (2117:1345) |
1.09 | 0.98 | 1.20 | 0.12 |
| rs11732095 | 123567795 | ADAD1 | Intron | A | 0.97 (2732:82) |
0.97 (3411:117) |
1.14 | 0.86 | 1.52 | 0.36 |
| rs4833248 | 123599855 | IL2 | Flanking 5' UTR | A | 0.07 (208:2598) |
0.07 (252:3180) |
1.01 | 0.83 | 1.22 | 0.92 |
| rs10857092 | 123608669 | IL2 | Flanking 5' UTR | A | 0.06 (162:2666) |
0.05 (186:3348) |
1.09 | 0.88 | 1.36 | 0.42 |
| rs6814718 | 123642766 | IL2 | Flanking 5' UTR | G | 0.77 (2179:643) |
0.76 (2691:839) |
1.06 | 0.94 | 1.19 | 0.36 |
| rs4833834 | 123685801 | IL21 | Flanking 3' UTR | G | 0.02 (55:2773) |
0.02 (68:3466) |
1.01 | 0.71 | 1.45 | 0.95 |
| rs13140464 | 123719195 | IL21 | Flanking 3' UTR | C | 0.97 (2726:80) |
0.97 (3380:104) |
1.05 | 0.78 | 1.41 | 0.75 |
| rs6822844 | 123728871 | IL21 | Flanking 3' UTR | C | 0.97 (2745:81) |
0.97 (3418:114) |
1.13 | 0.85 | 1.51 | 0.41 |
| rs6835457 | 123730576 | IL21 | Flanking 3' UTR | A | 0.61 (1730:1096) |
0.58 (2051:1479) |
1.14 | 1.03 | 1.26 | 0.012 |
| rs975404 | 123740742 | IL21 | Flanking 3' UTR | A | 0.62 (1743:1081) |
0.60 (2128:1398) |
1.06 | 0.96 | 1.17 | 0.27 |
| rs907715 | 123754503 | IL21 | Intron | G | 0.62 (1762:1060) |
0.59 (2083:1439) |
1.15 | 1.04 | 1.27 | 0.0076 |
| rs11930631 | 123754745 | IL21 | Intron | A | 0.31 (861:1949) |
0.29 (1014:2466) |
1.07 | 0.96 | 1.20 | 0.20 |
| rs4833837 | 123756413 | IL21 | Coding | A | 0.93 (2629:199) |
0.92 (3267:267) |
1.08 | 0.89 | 1.31 | 0.43 |
| rs2221903 | 123758362 | IL21 | Intron | A | 0.93 (2629:199) |
0.92 (3265:267) |
1.08 | 0.89 | 1.31 | 0.43 |
| rs13143866 | 123760208 | IL21 | Intron | G | 0.79 (2211:579) |
0.77 (2665:779) |
1.12 | 0.99 | 1.26 | 0.076 |
| rs6840978 | 123774157 | IL21 | Flanking 5' UTR | G | 0.86 (2430:394) |
0.85 (2999:535) |
1.10 | 0.96 | 1.27 | 0.18 |
| rs13137822 | 123776686 | IL21 | Flanking 5' UTR | C | 0.70 (1963:851) |
0.70 (2437:1067) |
1.01 | 0.91 | 1.12 | 0.86 |
| rs2137497 | 123777704 | IL21 | Flanking 5' UTR | A | 0.71 (2002:812) |
0.71 (2466:1030) |
1.03 | 0.92 | 1.15 | 0.60 |
| rs2390352 | 123777780 | IL21 | Flanking 5' UTR | G | 0.53 (1500:1326) |
0.53 (1860:1662) |
1.01 | 0.92 | 1.12 | 0.83 |
| rs7694252 | 123780886 | IL21 | Flanking 5' UTR | G | 0.22 615:2197) |
0.21 (751:2763) |
1.03 | 0.91 | 1.16 | 0.63 |
| rs6419221 | 123783569 | IL21 | Flanking 5' UTR | G | 0.61 (1727:1093) |
0.61 (2138:1386) |
1.02 | 0.93 | 1.13 | 0.64 |
| rs1533236 | 123783908 | IL21 | Flanking 5' UTR | G | 0.38 (1070:1758) |
0.38 (1329:2205) |
1.01 | 0.91 | 1.12 | 0.85 |
| rs7685609 | 123784752 | IL21 | Flanking 5' UTR | G | 0.98 (2694:68) |
0.96 (3302:130) |
1.56 | 1.16 | 2.10 | 0.0032 |
| rs10518400 | 123801876 | IL21 | Flanking 5' UTR | G | 0.95 (2668:156) |
0.94 (3220:210) |
1.08 | 0.87 | 1.34 | 0.47 |
| rs9307509 | 123807941 | IL21 | Flanking 5' UTR | T | 0.97 (2599:91) |
0.96 (3122:118) |
1.08 | 0.82 | 1.43 | 0.59 |
| rs6837455 | 123808392 | IL21 | Flanking 5' UTR | C | 0.22 (612:2212) |
0.20 (707:2811) |
1.10 | 0.97 | 1.24 | 0.13 |
| rs6534359 | 123816144 | IL21 | Flanking 5' UTR | A | 0.94 (2651:157) |
0.93 (3277:233) |
1.20 | 0.97 | 1.48 | 0.086 |
| rs309414 | 123840362 | BBS12 | Flanking 3' UTR | C | 0.76 (2147:673) |
0.74 (2600:918) |
1.13 | 1.00 | 1.26 | 0.042 |
| rs17006053 | 123849111 | BBS12 | Flanking 3' UTR | C | 0.75 (2099:689) |
0.75 (2600:862) |
1.01 | 0.90 | 1.13 | 0.87 |
OR, odds ratio; LL, lower limit; UL, upper limit, CI, confidence interval. The numbers between parenthesis represent the number of risk (associated) and protective (non-associated) alleles, respectively.