Figure 4.

T cell reactivity with 3 self-peptides or the Borrelia burgdorferi outer-surface protein A (OspA)_161–175 peptide in each of 11 patients with antibiotic-refractory Lyme arthritis. Among 11 patients, 9 had T cell–proliferative responses to the OspA peptide, 6 had reactivity with the MAP kinase activator with WD-repeats (MAWD-BP) peptide, 3 had responses to the T-span peptide, and 2 had reactivity with the LFA-1 peptide. However, reactivity with the self-peptides was less than that with the spirochetal peptide. Reproduced with permission from Drouin et al [17].