Table 1.
Patient Characteristics of Nonresponders to Immunosuppressive Therapy
| Variable | All patients |
Group 1(1989–1996) |
Group 2(1996–2002) |
Group 3(2002–2008) |
Pa | ||||
| No. (%) of patients | Mean value ± SE | No. (%) of patients | Mean value ± SE | No. (%) of patients | Mean value ± SE | No. (%) of patients | Mean value ± SE | ||
| Total | 174 | 43 | 51 | 80 | |||||
| Age, years | 38.9 ± 1.5 | 46.0 ± 2.9 | 37.7 ± 2.7 | 35.4 ± 2.4 | .019 | ||||
| Sex | |||||||||
| Male | 103 (59) | 22 (51) | 32 (63) | 49 (61) | .732 | ||||
| Female | 71 (41) | 21 (49) | 19 (37) | 31 (39) | |||||
| Baseline (/uL) | |||||||||
| ANC | 290 ± 23 | 253 ± 44 | 279 ± 42 | 320 ± 36 | .019 | ||||
| ANC <200 | 82 (47) | 23 (53) | 19 (37) | 40 (50) | .705 | ||||
| ALC | 1143 ± 43 | 1072 ± 99 | 1120 ± 81 | 1199 ± 57 | .138 | ||||
| ARC | 14,304 ± 1148 | 12,505 ± 1.789 | 14,012 ± 1,983 | 15,554 ± 1,979 | .500 | ||||
| Platelet count | 10,094 ± 650 | 10,283 ± 1003 | 12,040 ± 1589 | 8662 ± 791 | .052 | ||||
| Salvage therapy | |||||||||
| Repeat IST | 72 (41) | 1 (2) | 22 (42) | 49 (61) | |||||
| HSCT | 43 (25) | 3 (7) | 14 (26) | 28 (35) | |||||
NOTE. Baseline values are given. ALC, absolute lymphocyte count; ANC, absolute neutrophil count; ARC, absolute reticulocyte count; IST, immunosuppressive therapy; HSCT, hematopoietic stem cell transplantation; SE, standard error.
a
Log (X + 1) transformations for X=ANC, ALC, ARC, platelet count were used for calculating the P values.