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. Author manuscript; available in PMC: 2011 Jun 2.
Published in final edited form as: Trends Mol Med. 2009 Aug 31;15(9):391–404. doi: 10.1016/j.molmed.2009.06.007

Table 2.

Amelioration of disease/tissue injury in humans and in animal models by treatments that affect S-nitrosylation.

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1

Effects in humans.

2

Ex vivo repletion of S-nitroso-hemoglobin in red blood cells.

3

Induces S-nitrosylation (e.g. of COX-2) by eNOS and iNOS.

4

A glutathione (GSH) precursor that reverses nitrosative stress.

5

Lowers iNOS-mediated S-nitrosylation.

6

Binds to GAPDH and blocks iNOS-induced S-nitrosylation.

7

Potentiates the interaction between SNO-RyR1 and FKBP12 to ameliorate calcium leak.