Enhanced Potency of Nucleotide–Dendrimer Conjugates as Agonists of the P2Y14 Receptor: Multivalent Effect in G Protein-Coupled Receptor Recognition

. Author manuscript; available in PMC: 2011 Jun 2.

Published in final edited form as: Bioconjug Chem. 2009 Jul 2;20(8):1650–1659. doi: 10.1021/bc900206g

Scheme 1. Covalent Coupling of the Carboxylic Acid Functionalized Congener UDPGA 2 to PAMAM Dendrimers of Integral Generations 3 and 6, by Carbodiimide Condensation with the Surface Amino Groups of the Dendrimer.