Enhanced Potency of Nucleotide–Dendrimer Conjugates as Agonists of the P2Y14 Receptor: Multivalent Effect in G Protein-Coupled Receptor Recognition

. Author manuscript; available in PMC: 2011 Jun 2.

Published in final edited form as: Bioconjug Chem. 2009 Jul 2;20(8):1650–1659. doi: 10.1021/bc900206g

Scheme 3. Synthesis of an Amine-Functionalized Congener UDPGA 3a and Its Covalent Coupling to PAMAM Dendrimers of Half-Generations 2.5 and 5.5, by Carbodiimide Condensation with the Surface Carboxylic Groups of the Dendrimer.