Figure 5.

A, Correlation of affinity of C•A internal loops for KanHex and the thermodynamic stabilities of the loops. The sequences for the loops are shown in Table 1. B, The affinity of C•A internal loops with KanHex as a function of thermodynamic stability at different pH’s. ΔΔG⁰_37,pH is calculated by taking the difference between the ΔG⁰_37,pH=5.5 and ΔG⁰_37,pH=7.0. There is no correlation between affinity and the likelihood that a loop forms a C-A⁺ pair at lower pH.