Fig. 6.

Effects of coffee consumption on ERKs phosphorylation in CRC tissues. (A) Photographic data (×200) of immunohistochemistry staining of ERKs in tumor tissues from representative colon cancer patients who reported drinking more than one cup of coffee daily (right) and no coffee consumption (left). (B) Level of ERKs phosphorylation. The asterisk (*) indicates a significant decrease (P < 0.005) in ERKs phosphorylation in patients who consumed either decaffeinated or regular coffee compared with the ‘no coffee consumption’ group. No significant difference was observed in ERKs phosphorylation in patients who consumed regular or DC.