Table II.

OR of colorectal adenoma for polymorphisms in DNA repair genes with P < 0.01, PLCO Cancer Screening Trial baseline exam 1993–2001

				Caucasian subjectsa			All subjectsb
SNP	Gene	Risk allele	RAFc	OR	95% CI	P	OR	95% CI	P
rs9350 T→C	EXO1	C	0.82	1.30	1.11–1.51	0.001	1.24	1.07–1.44	0.003
rs400727 T→G	FANCC	G	0.91	1.44	1.15–1.80	0.002	1.40	1.14–1.72	0.001
rs3762053 G→T	RAD54B	G	0.16	1.25	1.09–1.44	0.002	1.23	1.07–1.41	0.004
rs11614717 T→G	POLE	T	0.14	1.27	1.09–1.49	0.002	1.24	1.07–1.44	0.005
rs4703564 T→C	XRCC4	C	0.89	1.42	1.13–1.78	0.002	1.31	1.09–1.59	0.005
rs242448 A→T	FANCC	T	0.92	1.42	1.13–1.78	0.002	1.41	1.14–1.75	0.002
rs4658535 A→G	EXO1	G	0.79	1.26	1.08–1.45	0.002	1.25	1.09–1.42	0.002
rs1699499 C→T	FANCC	T	0.97	1.70	1.20–2.40	0.003	1.67	1.19–2.35	0.003
rs17503908 G→T	ATM	G	0.08	1.34	1.11–1.62	0.003	1.33	1.10–1.60	0.003
rs10412761 G→A	ERCC1	A	0.57	1.19	1.06–1.33	0.003	1.19	1.07–1.33	0.001
rs3885676 C→T	XRCC4	T	0.87	1.36	1.11–1.66	0.003	1.31	1.10–1.56	0.003
rs4465523 A→G	APEX1	A	0.33	1.18	1.05–1.32	0.006	1.20	1.08–1.34	0.001
rs17277375 T→C	APEX1	T	0.32	1.18	1.05–1.33	0.006	1.19	1.06–1.33	0.003
rs2301180 C→T	DCLRE1A	T	0.71	1.18	1.05–1.34	0.006	1.16	1.03–1.30	0.01
rs6864054 G→A	XRCC4	A	0.94	1.44	1.11–1.87	0.006	1.33	1.05–1.70	0.02
rs5744990 A→G	POLE	A	0.13	1.24	1.06–1.45	0.006	1.23	1.06–1.43	0.007
rs6573333 T→G	MNAT1	G	0.98	2.36	1.26–4.40	0.007	1.18	0.80–1.74	0.39
rs3102854 G→A	RAD54B	G	0.24	1.19	1.05–1.35	0.007	1.18	1.04–1.33	0.009
rs7829886 A→T	RAD54B	T	0.73	1.19	1.05–1.35	0.008	1.16	1.03–1.31	0.02
rs12050102 T→G	APEX1	T	0.33	1.17	1.04–1.32	0.008	1.19	1.06–1.33	0.002
rs4150628 G→A	GTF2H1	G	0.44	1.16	1.04–1.23	0.008	1.14	1.03–1.27	0.02
rs228606 T→G	ATM	T	0.39	1.16	1.04–1.30	0.008	1.15	1.04–1.28	0.009
rs3212986 A→C	ERCC1	C	0.74	1.19	1.04–1.35	0.008	1.19	1.05–1.34	0.006
rs10838192 C→T	ALKBH3	C	0.21	1.19	1.05–1.36	0.009	1.19	1.04–1.35	0.008
rs828918 G→C	XRCC5	G	0.13	1.24	1.06–1.45	0.009	1.19	1.02–1.38	0.03
rs3131382 T→C	MSH5	C	0.93	1.36	1.08–1.71	0.009	1.37	1.09–1.72	0.007
rs1150793 G→A	MSH5	G	0.06	1.34	1.08–1.67	0.009	1.26	1.02–1.55	0.03
rs707915 A→T	MSH5	A	0.06	1.34	1.08–1.67	0.009	1.26	1.02–1.55	0.03
rs11615 G→A	ERCC1	A	0.58	1.16	1.04–1.31	0.009	1.15	1.02–1.28	0.02
rs5744903 T→C	POLE	T	0.06	1.32	1.07–1.62	0.01	1.28	1.04–1.57	0.02

^aOR per risk allele assuming a log-additive model, adjusted for age and sex.

^bOR per risk allele assuming a log-additive model, adjusted for age, sex and race.

^cRAF, risk allele frequency among Caucasian controls.