Table 4.

Comparison of NRI and IDI for GDF-15, NT-proBNP and CRP

	IDI	p	NRI*	p	Categoryless NRI	p
All-Cause Death
GDF-15	0.016	0.003	0.056	0.009	0.296	<0.0001
NT-proBNP	0.012	0.003	0.041	0.03	0.220	<0.0001
CRP	0.002	0.12	0.000	0.99	0.105	0.07
CVD Death
GDF-15	0.005	0.34	0.001	0.96	0.166	0.05
NT-proBNP	0.024	0.01	0.039	0.10	0.323	<0.0001
CRP	0.005	0.08	−0.016	0.24	0.056	0.53
Non-CVD Death
GDF-15	0.017	0.002	0.036	0.15	0.333	<0.0001
NT-proBNP	0.004	0.13	0.023	0.19	0.238	0.0006
CRP	0.001	0.48	−0.009	0.50	0.136	0.05

^*Cut-points for low/high risk were <10%/>30% for all-cause death, and by tertiles of risk for CVD death (<2%/>9%) and non-CVD death (<5%/>16%).

Comparisons are to a baseline model adjusted for: age, sex, diabetes, hypertension, current smoking, systolic blood pressure, total cholesterol, HDL, CrCl and BMI.

CVD = cardiovascular disease; IDI = integrated discrimination improvement; NRI = net reclassification improvement.