Figure 3.

Localization of 23 Jacobsen syndrome chromosome breakpoints on the YAC contig of distal chromosome 11q. (Solid bar) The intact region of the deleted chromosome with the most distal marker known to be retained (+). (Shaded bar) The maximum extent of the region in which the breakpoint must be located with the most proximal deleted marker (usually bounded by −). (X) A breakpoint is defined with the resolution of a single position on the YAC contig, i.e., to FRA11B for patients 3 and 8, and close to D11S1336 for patient RB. Patients numbered 1–17 are from Penny et al. (1995), of which patients 3 and 8 were shown to have breakpoints at fragile site FRA11B (Jones et al. 1995); patients VH and AD are from Michaelis et al. (1998); patient C is from Breton-Gorius et al. (1995); patient GS is from T. Mattina, C. Jones, and A. Tunnacliffe (in prep.); and patients RB and MC are described in this paper.