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Docking studies with amprenavir. The MDR769 I10V mutant is shown in a greenish cyan color (cartoon representation) with two molecules of amprenavir (shown as spheres) docked into the expanded active-site cavity with the proline switch. Asn25 and Asn125 are highlighted as yellow stick models. Residues Val10 and Pro81 are highlighted as red stick models. The active-site cavity is magnified in the inset for clarity.
