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The structure of the 6s-98S FIV PR dimer (green) with darunavir (DRV) bound (C atoms in cyan) superposed onto the structure of HIV PR with DRV bound (PDB code 2ien; gray). Cα positions of residues mutated in the 6s-98S chimera are indicated in blue; six additional residues mutated in the 12s chimera of FIV PR are indicated in red (Table 1 ▶). Mutations are in three regions of each monomer: the catalytic core (residue 37), the flaps and the 90s loop. Monomers A and B are labeled.
