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. 2011 May 20;13(6):610–621. doi: 10.1093/neuonc/nor035

Fig. 6.

Fig. 6.

Inhibition of phospho-p70S6K (Thr389) by increasing concentrations of rapamycin (A). KR158 cells were starved and then stimulated with 10% FBS in the presence of different concentrations of rapamycin. Growth inhibition curves as a function of rapamycin (B). Rapamycin showed highly variable results, with inhibition even at very low concentrations, such that data did not show a sigmoidal dose response. Murine primary astrocytes: Ms 1 Astro; murine astrocytoma grade II: K1861; murine astrocytoma grade III: KR158; murine GBM grade IV: KR130; human GBM grade IV: SF-295 and U87MG.