Table 2.
IC50, GI50, and maximum percent inhibition of compounds in different cell lines
| Astrocytes | K1861 | KR158 | KR130 | SF295 | U87MG | pAKT/pS6K | ||
|---|---|---|---|---|---|---|---|---|
| Mouse | Mouse | Mouse | Mouse | Human | Human | |||
| Inhibitor | Normal | Grade II | Grade III | Grade IV | Grade IV | Grade IV | ||
| PI-103 | IC50 | 3.12 µM | 0.80 µM | 0.59 µM | 0.62 µM | 0.80 µM | 0.63 µM | 0.005 µM |
| GI50 | 5.15 µM | 0.97 µM | 0.66 µM | 0.68 µM | 0.89 µM | 1.10 µM | ||
| Max% | 83.3 | 95.4 | 86.8 | 94.8 | 94.6 | 86.0 | 100 | |
| TCN | IC50 | 5.33 µM | 0.70 µM | 0.31 µM | 0.74 µM | 0.75 µM | 27.67 µM | 0.13 µM |
| GI50 | 13.58 µM | 1.73 µM | 0.36 µM | 1.07 µM | 0.99 µM | NA | ||
| Max% | 70.7 | 69.0 | 87.1 | 82.3 | 85.9 | 43.2 | 98 | |
| Rapamycin | IC50 | NA | NA | 0.26 nM | 0.47 nM | 0.35 nM | 0.58 nM | <1 pM |
| GI50 | NA | NA | NA | NA | NA | 119.03 nM | ||
| Max% | NA | NA | 33.6 | 45.6 | 46.6 | 50.6 | 100 |
NA, not available.