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. 2011 May 20;13(6):680–689. doi: 10.1093/neuonc/nor045

Table 4.

Clinical characteristics of pediatric thalamic high-grade gliomas

Characteristic Value Event-free survival
Overall survival
5-year EFS %±SD Pa 5-year OS %±SD Pa
Tumor extension NS NS
 Thalamus alone (including bithalamic lesions) n =31 7.3±5 7.4±5.1
 Thalamus plus adjacent diencephalic/mesencephalic structures n =38 5.4±3.7 6.9±5.9
 Thalamus plus cortical and/or cerebellar and/or pontine structures n =30 10.3±5.7 15.9±7.7
Extent of surgical resection .0479 .0272
 Tumor resection n =50 10.4±4.6 13.6±5.9
 No tumor resection n =49 4.2±2.9 9.2±4.6
Grading NS .0462
 WHO III n =67 8.8±3.7 14.6±5.6
 WHO IV n =32 3.2±3.2 3.8±3.8
Sex NS NS
 Male n =45 2.5±2.4 6±4
 Female n =54 11.6±4.9 17.3±6.3
Age at diagnosis NS NS
 <11 years n =47 6.8±3.8 6.8±3.8
 ≥11 years n =52 6.5±3.9 6.5±3.9
Initial/postsurgical tumor size
 Maximum tumor diameter n =84
  Range 0.6–8.9 cm
  Mean 4.3 cm
  <4.3 cm (mean) n =42 8.1±4.5 NS 8.7±5.2 NS
  ≥4.3 cm (mean) n =42 9.5±4.5 8.0±5.2
 Tumor volume n =51
  Range 0.3–224.3 cm3
  Mean 36.3 cm3
  <36.3 cm3 (mean) n =25 12.2±7.7 NS 9.7±8.3 NS
  ≥36.3 cm3 (mean) n =26 3.9±3.8 0
Tumor volume at week 8 (after radiotherapy)
 Maximum tumor diameter n =53
  Range 0.3–8.0 cm
  Mean 4.0 cm
  <4.0 cm (mean) n =25 6.3±5.6 NS 0 NS
  ≥4.0 cm (mean) n =28 3.6±3.5 4.3±4.2
 Tumor volume n =41
  Range 0–195.4 cm3
  Mean 22.1 cm3
  <22.1 cm3 (mean) n =20 14.2±8.5 .0263 14.2±11.5 NS
  ≥22.1 cm3 (mean) n =21 0 0
Response at week 8 (after radiotherapy) < .0001 NS
 CR n =7 42.9±18.7 50.0±20.4
 PD n =10 0 0
 PR n =30 10.0±4.5 20.0±12.6
 SD n =43 7.0±3.9 15.3±6.7
 Unknown n =9 0 0
Pattern of relapsed/progressive disease NS NS
 Only local relapse/progression n =72 8.8±3.5 14.7±5.1
 With or without secondary metastases n =27 3.7±3.6 0
  Cerebrospinal fluid/leptomeningeal metastases n =18
  Íntracerebral metastases n =6
  Cerebrospinal fluid/leptomeningeal and intracerebral metastases n =3
Cox regression analysis NA NA NA
 Tumor extension NS NS
 Tumor resection .015 .002
 Grading .013 .009
 Sex NS NS
 Age NS NS
 Response at week 8 .001 NS

CR indicates complete response; EFS indicates event-free survival; NA indicates not applicable; NS indicates not significant; OS indicates overall survival; PD indicates progressive disease; PR indicates partial response; SD indicates stable disease.

aDetermined by log-rank test.