Table 1. Rescue of various phenotypes of the Fig4 null mice by the Tg705 and Tg721 I41T transgenes.

Fig4 genotype	−/−	−/−, Tg705	−/−, Tg721	+/+
brain transcript	0	2×	5×	1×
FIG4 protein	none	I41T	I41T	wildtype
survival	1–2 months	3–6 months	>2 years	>2 years
degeneration of cerebral cortex	extensive	intermediate	none	none
degeneration of DRG	extensive	intermediate	none	none
degeneration of deep cerebellar nuclei	extensive	intermediate	intermediate	none
autophagic inclusion bodies	extensive	intermediate	few	none
hydrocephalus	present	present	present	rare
coat color	pale	pale	intermediate	wildtype
nerve conduction velocity	reduced	intermediate	intermediate	normal.
sciatic nerve myelination	defective	normal	normal	normal